欢迎访问沈阳麻将官网

乐桂堂家具

厂家直销 质量可靠 诚信经营

让广大养殖户用得放心、平价、优良。

18169824988 18029287672

当前位置:主页 > 新闻资讯 >

返回列表页

化合物定制合成网

  酰胺的活性比羧酸差,因此酰胺的水解一般需要强酸或强碱参与并在加热的条件下进行。酰胺水解也有碱水解和酸水解两种情况,在有些情况下,加入亚硝酸钠可以促进酰胺水解。

  由于酰胺直接水解较为强烈,对于一些复杂的分子无法使用,因此对氮上有活泼氢的酰胺可将其衍生化后水解,一般衍生化的方法是用引入Boc,其反应如下:

  A suspensionof2-(5-oxo-10,11-dihydrodibenzo[a,d]cyclohepten-2-yl)propionamide(15 g,53.7 mmol) in a mixture of sulphuricacid(d = 1.36, 50 mL) and water (60 mL) was heatedwith vigorous stirring for 3 hours at 110°C. After cooling, the product whichprecipitated was filtered off and then added to 2 N sodium hydroxide solution (55 mL). The alkaline solution, clarified by filtration, was acidified by adding 2 N hydrochloric acid (60 mL). The product which precipitated was filtered off, dried and then recrystallized from CCl4 (170 mL) to give 2-(5-oxo-10,11-dihydrodibenzo[a,d]cyclohepten2-yl)propionic acid (7.4 g, 49.2%) melting at 122°C.

沈阳麻将

返回顶部